Description:

p53 functions as a tumor suppressor primarily through its transcriptional regulation of a number of target genes, which encode proteins and miRNAs important for executing the p53 response to a variety of stress signals. This transcriptional activity is exerted via the direct binding of p53 to the canonicalp53 responsive DNA elements of its target promoters.  Thus, monitoring the binding of p53 to its target gene promoters becomes one critical measurement of p53 transcriptional functions or specific target genes.